Apply These Secret Techniques To Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is in fact quite common, with 10-25% of recognized pregnancies ending in miscarriage. When you have suffered a pregnancy loss or are in the process of having a miscarriage, you may be wondering what caused the loss and worry about whether it’ll happen again. This short article aims to answer the next questions:

What causes miscarriage?
How common is pregnancy loss?
What type of genetic testing can be acquired for miscarriage tissue?
How can chromosome testing help?
Causes of Miscarriage

There are many different explanations why miscarriage occurs, but the most common cause for first trimester miscarriage is a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur due to a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes which come in 23 pairs (22 pairs numbered from 1 to 22 and the sex chromosomes, X and Y). For a baby to develop normally it is crucial that it have the right level of chromosome material; missing or extra material at the time of conception or within an embryo or fetus could cause a woman to either not become pregnant, miscarry, or have a baby with a chromosome syndrome such as for example Down syndrome.

Over 50% of all first trimester miscarriages are caused by chromosome abnormalities. This number may be closer to 75% or higher for women aged 35 years and over who’ve experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep upsurge in women older than 35.

pregnancy Pregnancy Loss – How Common could it be?

Miscarriage is far more common than most people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The chance of having a miscarriage also increases as a mother gets older.

Nearly all women who experience a miscarriage go on to get a healthy pregnancy rather than miscarry again. However, some women seem to be more susceptible to miscarriage than others. About five percent of fertile couples will experience several miscarriages.

Of note, the rate of miscarriage seems to be increasing. One reason for this can be awareness – more women know they’re having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas previously the miscarriage would have were just an unusual period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Helpful for Miscarriages

Genetic testing actually refers to many types of testing that you can do on the DNA in a cell. For miscarriage tissue, also called products of conception (POC), probably the most useful type of test to perform is really a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the current presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason behind the pregnancy loss.

The most common method of chromosome analysis is called karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. Due to this requirement, tissue that’s passed at home is frequently unable to be tested with this particular method. About 20% or even more of miscarriage samples fail to grow and thus no results are available. Additionally, karyotyping is unable to tell the difference between cells from mom (maternal cells) and cells from the fetus. In case a normal female result is available, it may be the correct result for the fetus or it might be maternal cell contamination (MCC) where the result actually comes from testing the mother’s cells present in the pregnancy tissue rather than the fetal cells. MCC seems to occur in about 30% or even more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months another from the laboratory.

Microarray testing is a new kind of genetic testing done on miscarriage samples; both most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also able to test all 23 pairs of chromosomes for aneuploidy, but will not require cell culture. Therefore, you’re more likely to receive results and the results are typically returned faster when microarray testing is used. Additionally, some laboratories are collecting an example of the mother’s blood as well the miscarriage tissue is delivered to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How do it help?

In case a chromosome abnormality is identified, the sort of abnormality found can be assessed to help answer fully the question: “Will this happen to me again?”. More often than not, chromosome abnormalities in an embryo or fetus are not inherited and have a minimal possiblity to occur in future pregnancies. Sometimes, a specific chromosome finding in a miscarriage alerts your doctor to do further studies to investigate the possibility of an underlying genetic or chromosome problem in your loved ones that predisposes one to have miscarriages.

Furthermore, in case a chromosome abnormality is identified it could prevent the dependence on other, sometimes quite costly, studies your physician might consider to investigate the cause of the miscarriage.

Lastly, knowing the reason behind a pregnancy loss can help a couple of start the emotional healing process, moving past the question of “Why did this eventually me?”.

Chromosome testing could be especially very important to patients with repeated miscarriages, as it could either give clues to an underlying chromosomal cause for the miscarriages or eliminate chromosome errors as the reason behind the miscarriages and invite their doctor to pursue other types of testing. For couples with multiple miscarriages determined to truly have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing may be able to help increase their chances of having an effective healthy pregnancy.